An Imputation Approach for Oligonucleotide Microarrays
نویسندگان
چکیده
منابع مشابه
An Imputation Approach for Oligonucleotide Microarrays
Oligonucleotide microarrays are commonly adopted for detecting and qualifying the abundance of molecules in biological samples. Analysis of microarray data starts with recording and interpreting hybridization signals from CEL images. However, many CEL images may be blemished by noises from various sources, observed as "bright spots", "dark clouds", and "shadowy circles", etc. It is crucial that...
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Objective(s): Microarrays are potential analyzing tools for genomics and proteomics researches, which is in needed of suitable substrate for coating and also hybridization of biomolecules. Materials and Methods: In this research, a thin film of oxidized agarose was prepared on the glass slides which previously coated with poly-L-lysine (PLL). Some of the aldehyde groups of the activated aga...
متن کاملan efficient covalent coating on glass slides for preparation of optical oligonucleotide microarrays
objective(s): microarrays are potential analyzing tools for genomics and proteomics researches, which is in needed of suitable substrate for coating and also hybridization of biomolecules. materials and methods: in this research, a thin film of oxidized agarose was prepared on the glass slides which previously coated with poly-l-lysine (pll). some of the aldehyde groups of the activated agaro...
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UNLABELLED ROSO is software to design optimal oligonucleotide probe sets for microarrays. Selected probes show no significant cross-hybridization, no stable secondary structures and their Tm are chosen to minimize the Tm variability of the probe set. AVAILABILITY The program is available on the internet. Sources are freely available, for non-profit use, on request to the authors. SUPPLEMENT...
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SUMMARY OligoArray is a program that computes gene specific and secondary structure free oligonucleotides for genome-scale oligonucleotide microarray construction or other applications. AVAILABILITY The program code is distributed under the GNU General Public License and is freely available for non-profit use via request from the authors.
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0058677